What is blood derived biomaterial , are there different types?

Updated: Jan 3

Prof Paul Lee - MSK Regeneration Blog on MSK Doctors



There are many different types of blood derived biomaterial. The most common biomaterial that we see used in clinic is platelet-rich plasma. There are many different ways to process platelet-rich plasma and the quality of the platelet-rich plasma varies between clinics and between devices. Some clinics are still using the first generation device and currently, at MSK Doctors, we are using the 5th generation device. The 6th generation platelet-rich plasma device is currently in research and development.


With the newer platelet-rich plasma device we will have better control to the quality of the PRP that we produce, as well as the way that we filter the blood product. More importantly is the stability. Every time we improve our technique we manage to reduce a step in the preparation process, and therefore reduce the chance for error. There are 10 randomised controlled trials (RCT) which show that platelet-rich plasma is effective in the treatment of knee osteoarthritis, and certainly there are many trials to suggest that platelet-rich plasma can be very useful in the treatment of tendon and ligament injuries.


Another type of blood derived product that we can use is tissue bio-glue. Instead of taking the platelet, we can activate the platelet and produce a glue-like substance within the blood. Of course the balance of the activator and the time of the filter is essential with this product. Essentially, we can now produce a tissue bio-glue that is able to help and augment the repair. I am sure in the not too distant future we will be able to produce a tissue bio-glue that is strong enough to hold tissues together.


Another really exciting blood product that has become more available recently is a platelet scaffold for cell regeneration, which is used very commonly in cartilage repair as well as wound healing. By processing the blood in a specified way, we are now able to produce a specific scaffold that can form the base and the foundation for cell therapy. With this specific scaffold that is produced from your own blood, it will further enhance our ability to perform cell therapy. There are many exciting developments within blood derived biomaterial and the landscape is changing rapidly. It is important to keep up to date and have the best advice when choosing to use these products, and I would suggest that patients consult with their regenerative medicine doctor.


The Regeneration Man


#PRP #MSKDoctors #Biology



Regeneration Man
The Regeneration Man


Prof Paul Lee

MBBch, MFSEM (UK), MSc (Sports Med), PhD (Med Engine), FEBOT, FRCS (Tr & Orth)


Consultant Sports and Arthroplasty Surgeon

MSK and Regeneration Medicine Doctor

Visiting Professor of Sports Medicine

I.C.R.S. teaching centre of excellence

Regional advisor Royal College of Surgeon Ed


Passionate about biology, engineering, computers and medicine.




Sports Muscle Injuries and Actovegin: Basics, Concepts and Future of Actovegin by Paul Y. F. Lee (2016-02-22)




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